She made her debut in Gautham Menon’s 2012 bilingual films Neethaane En Ponvasantham and Yeto Vellipoyindhi Manasu, in which she played the role of Jenny, a friend of Samantha Akkineni. She was also seen in minor roles in Jilla and Veeram. The actress has been the part of more than 30 movies alone in Telugu including Duvvada Jagannadham, Ninnu Kori, Anando Brahma, Raja The Great, Bhaagamathie and Tholi Prema.
The sexy comedian considers Samantha Akkineni her Peddakka. Recently during the media interaction, Vidyullekha opened up about her relationship with Samantha. She said, Sam takes care of her enquiring her stay in Hyderabad and assuring her to be there for Vidyullekha whenever she needs her.